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The role of mineralocorticoid receptor function in treatment-resistant depression

  • Foto do escritor: Dr. Galiano Brazuna Moura
    Dr. Galiano Brazuna Moura
  • 21 de mai. de 2023
  • 1 min de leitura

Atualizado: 23 de mar.


high-detail scientific illustration depicting neuroinflammation. In the center, a blue, flower-like molecule with a glowing red core represents a pro-inflammatory cytokine (such as TNF-α) attacking a neural cell. Other similar blue and gold molecular structures float in the foreground and background against a dark, microscopic environment with faint neural fibers. The red glow in the center of the brain-like structure in the background suggests a localized inflammatory response.

Controlled Clinical Trial J Psychopharmacol 2013 Dec;27(12):1169-79. doi: 10.1177/0269881113499205. Epub 2013 Jul 31.

Our data confirmed that treatment-resistant depression is associated with hypercortisolism and these patients no longer show an hypothalamic-pituitary-adrenal response to the administration of a mineralocorticoid receptor antagonist, suggesting that there is a mineralocorticoid receptor malfunctioning, such as a down regulation, however, pharmacokinetics and pharmacodynamics in these subjects could also have had an effect on the lack of mineralocorticoid receptor response.

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