Depressao ligada a falta de ativaçao dos receptores mineralocorticoides no cerebro

Artigo do Dr. Juruena que aponta a relaçoa de depressao e a hipofunçao dos receptores de glico e mineralocorticoides no cerebro.

Enhanced cortisol action in the brain might prove to be a successful approach to maximise therapeutic antidepressant effects. Hypotheses regarding the mechanism of these receptor changes involve non-steroid compounds that regulate GR function via second messenger pathways. Research in this field will lead to new insights into the pathophysiology and treatment of affective disorders.

• DOI: 10.1590/s1516-44462004000300009